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Both Rybelsus and Januvia enhance incretin hormone activity, but through different mechanisms: Rybelsus directly activates GLP-1 receptors to stimulate insulin secretion when blood glucose levels are high, while Januvia works by preventing the breakdown of naturally occurring incretin hormones, thereby enhancing insulin secretion and suppressing glucagon release

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The pre-dosed oral format removes the handling steps required by other presentations and simplifies study design wherever an oral route of exposure is preferred