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Finally, to assess whether the increased intrinsic reactivity of -halothioamide warheads translates into more pronounced cellular engagement, we synthesized alkyne-tagged analogues of 11, 12 , and 14 (resulting in probes 16-18 , Fig

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Clinically, SIRS includes respiratory symptoms, ranging in severity from mild tachypnea to respiratory failure, persistent pulmonary hypertension, irritability, lethargy, temperature instability, poor perfusion and hypotension, disseminated intravascular coagulation, poor feeding, vomiting and ileus

The comments and suggestions provided by the anonymous reviewers significantly improved this manuscript and we greatly appreciate their efforts