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Gouty arthritis is the most painful manifestation of gout and is caused when urate crystals interact with neutrophils triggering an inflammatory response

Despite most autoantibodies associated with RA and CD being considered as non-specific, due to their ability to recognise multiple components, there have been reports of circulating antibodies which target TJs and neuronal structures as well as organs such as the pancreas, stomach, and liver in those diagnosed with the latter of these two conditions (Shaoul and Lerner 2007)

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