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Another mechanism involves flavoproteins whose stability relies on FAD mediated folding, such as AIFM1

Vitamin B12 Vitamin B12 (cobalamin) is an essential water-soluble vitamin required for red blood cell production, DNA synthesis, and neurologic function

Specifically, we found that GSSG elevation suppressed the phosphorylation/activation of IKK-, a proximal kinase in the NF-B signaling pathway that phosphorylates IB-, leading to its proteasomal degradation and subsequent NF-B activation

As various factors such as genetic inheritance, environmental toxins, oxidative stress, and mitochondrial dysfunction are probably involved in the pathogenesis of the disease, it is very challenging to understand the pathogenesis of Parkinson's disease