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50 & Target Kd: 65 pM (HGF) [1] In Vitro Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering

To address the critical issue of BBB permeability, studies using [H]Dihexa and [C]inulin in rats revealed that Dihexa avidly concentrated in all examined brain regions including the prefrontal cortex, hippocampus, hypothalamus, striatum, thalamus, midbrain, brain stem, and cerebellum, compared to blood

Dihexa 10mg Dihexa 10 mg is a laboratory-grade research peptide chemical designed for experimental investigation of hepatocyte growth factor (HGF)related signaling pathways

Dihexa was synthesized as a small molecule compound that, in in vitro studies, demonstrated its ability to induce spinogenesis and synaptogenesis at picomolar concentrations