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For instance, some patients remain on starter doses longer than recommended, which reduces potential benefits

Heavy metals are also known to induce mitochondrial dysfunction, deplete antioxidant reserves, and alter immune signaling pathways like NF-B and AP-1, all of which amplify inflammatory responses (Korashy et al., 2008

It has been indicated that prolonged administration of MSG (4 mg/g) significantly induces apoptosis in a time- dependent manner in the rats thymocyte cells via disturbing the fine balances between prooxidant-antioxidant system, with excessive production of ROS and resulting oxidative stress status [46]

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