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(2022) observed that SQOR expression is significantly upregulated when Caco-2 cells spontaneously differentiate into an intestinal epithelial phenotype, suggesting that SQOR helps maintain metabolic homeostasis in normal intestinal cells by enhancing H 2 S detoxification

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That dual mechanism is part of why it became a notable option for type 2 diabetes and obesity, and its also why cardiovascular researchers want to know whether the combined receptor activity carries any specific heart benefit