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The current understanding points to a multifaceted pathogenesis involving neuroinflammation, oxidative stress, impaired neurogenesis and synaptic plasticity, neuronal apoptosis, hormonal imbalance, calcium dysregulation, white matter disruption, and mitochondrial impairment

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If the red-flag symptoms associated with GLP-1RAs (such as persistent vomiting) are observed, these agents should not be continued indiscriminately