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It interacts weakly with receptors such as ER/ER, but its principal actions arise from regulating intracellular signaling networks including NF-B, Nrf2, PI3K/AKT, PTEN, and TGF-/Smad

First, as we have shown above in Figures4 and5, the sulfation reaction saturates at fairly low APAP doses because of the low concentration of PAPS