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Regulation and function of AMPK in physiology and diseases

To account for the induction of ALT in the breast cancer cells (21NT and BT474) and non-induction in normal cells (IBR3 and HMEC), it is known that histone H1 is expressed at higher physiological levels in normal tissues and lower levels in breast cancer cells (Scaffidi 2016)

Benjamin MA, McKay DM, Yang PC, Cameron H, Perdue MH

A change in that basement membranes rigidity caused by a variation in its COL IV contents could therefore modify the DTC-GSC interface, such as to influence the Delta-Notch interaction (Fig.6ac), and thereby the PZ size

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