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The UK SmPCs for semaglutide (Wegovy/Ozempic) and tirzepatide (Mounjaro), as well as their EMA European Public Assessment Reports (EPARs), document well-characterised GI side effect profiles that include nausea, vomiting, diarrhoea, constipation, and dyspepsia

While rare, more serious conditions like pancreatitis require prompt evaluation and cannot be self-managed

Ideally, the prescriber is someone you can work with long term, says John Morton, MD, MPH, chief of Bariatric and Minimally Invasive Surgery at Yale Medicine and a board-certified obesity medicine specialist

While some unwanted side effects have come from the method, there have also been some that have been welcomed by users