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SLC7A11 and GPX4 were identified as potential targets of ILF3 on the basis of data from the hTFtarget database (Table S9)

Second, ROS and mitochondrial DNA (mtDNA), as damage-associated molecular patterns (DAMPs), along with pathogen-associated molecular patterns (PAMPs), may activate the NLRP3 inflammasome and induce the release of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-, potentially transforming localized metabolic stress into a systemic inflammatory response

A defining feature is the dual role of autophagy, which can either suppress or induce ferroptosis depending on the genetic background, LC subtype and microenvironmental cues

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