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As acute nausea subsides around weeks two to three, constipation and bloating often become the primary complaint, because semaglutide slows gastric emptying and reduces overall food intake, which leads to less frequent bowel movements and harder stools
416 Experimental models of depression also demonstrate uncoupling of astrocytic syncytia, whereas pharmacological inhibition of gap junctions by intracerebral infusion of carbenoxolone induced anhedonia and anxiety-like behaviour
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