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Patients were randomly assigned to undergo wide excision with margins of either 2 cm (n = 476) or 5 cm (n = 513).[3][Level of evidence A1] With a median follow-up of 11 years, there was no statistically significant difference in OS between the two treatment groups

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For example, a study published in the Journal of Clinical Endocrinology & Metabolism found that growth hormone significantly improves muscle recovery and repair, especially after intense physical activity

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