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If its well-tolerated, the dosage is gradually increased by the healthcare provider every four weeks (or sometimes less often), with maintenance doses ranging from 5 mg to 15 mg via weekly injection

This also proves slightly different mechanisms of lipoprotein circulation in the CNS and the impermeability of both the blood-brain barrier and the blood-cerebrospinal fluid barrier to cholesterol and plasma lipoproteins (except for the precursor of small spherical HDL particles)

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