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In the other direction, the brain may exert an influence on the gut, either via the autonomic and enteric nervous systems (downwards black arrows in Figure 2 ), or via activation of the Hypothalamus-Pituitary-Adrenal (HPA) axis (downwards red arrows in Figure 2 ), which will be examined in detail later
It plays a central role in maintaining structural integrity across skin, vasculature, and connective tissue
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Results Combinatorial CRISPR screening approach to interrogate SLC25 transporters We utilized a dual Cas9 enzyme-based knockout strategy 15 to probe all 53 human SLC25 family members in a pair-wise manner in pooled format
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