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Further, KD should not be used in patients with chronic kidney disease, liver failure, hypertriglyceridemia-induced acute pancreatitis, heart failure, especially NYHA Class IV, eating disorders, respiratory failure, as well as in the elderly, and during pregnancy and lactation ( KD is widely used as an adjuvant therapy for many diseases

Al-Shahat DS, Abo-Elmaaty AM, Kamel MA

Thus, measurement of GR activity is used as indicator for oxidative stress

SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors) : Similar to SSRIs, Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) increase serotonin availability and are also used to treat depression and anxiety, offering additional benefits for mood regulation during recovery