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The literature also describes upregulation of growth factors involved in tissue repair, modulation of nitric oxide synthase activity, and effects on the dopaminergic and serotonergic systems that are harder to interpret clinically [Sikiric et al., Inflammopharmacology, 2018]

Joint pain is an extremely prevalent symptom in the general population, affecting millions of people in the UK due to osteoarthritis, inflammatory arthritis, fibromyalgia, and other conditions

Indeed, CTGF has been shown to promote matrix production, proliferation, differentiation, and cell migration and to inhibit apoptosis, effects that prevent the development of IVD degeneration [6769]