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Regulation of YAP and RAS by tyrosine phosphorylation mediated by SRC family kinases Although YAP is essential for PDAC development, mutations in genes encoding Hippo pathway components are virtually nonexistent, underscoring the importance of defining upstream pathways that regulate the nuclear/cytoplasmic distribution and activity of YAP/TAZ

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A selective non-competitive inhibitor of VMAT2 VMAT1 is a different isoform expressed in peripheral neuroendocrine cells (adrenal chromaffin cells, interneurons of sympathetic ganglia, and enterochromaffin cells that store serotonin in the GI tract)

This work also helps clarify future developmental directions for the linkers