Many single-event mTBI patients experience symptoms or disability even for more than 1 year (Nelson et al., 2019), including chronic dizziness, fatigue, and headache (Silver et al., 2009), which are collectively referred to as postconcussive syndrome (Sterr et al., 2006
A similar metabolic response was observed by McGregor et al
Although robust preclinical evidence indicates that modulation of ferroptosis attenuates myocardial and vascular injury, clinical translation is constrained by incomplete understanding of context-specific roles, the paucity of validated biomarkers, and the absence of targeted therapeutics with acceptable safety profiles
Since Lactobacillus carries BSH and Firmicutes carries 7--dehydroxylase, this leads to a decrease in taurine-conjugated BAs in FXR L and FXR IN mice after VSG