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Synthetic biology techniques, such as gene editing and genetic engineering, can greatly improve biological activity and deliver MOTS-c directly to the acting site, thus further expanding the therapeutic application of MOTS-c
As the most abundant intracellular thiol antioxidant, GSH is the primary oxidative stress defense of the brain, coordinating synthesis, recycling, and redox signaling to maintain redox homestasis ( Proteomics and metabolomics enable systematic profiling of protein expression and metabolic signatures
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