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Numerous in vitro and in vivo studies have been performed that focused on the modulation of total and free IGF-1 levels and relative impact on tumor growth, invasiveness and response to therapeutics

Yet, in the body, (1) -tocopherol is preferentially retained in the liver by the binding to -tocopherol transfer protein (-TTP), which incorporates -tocopherol into lipoproteins for delivery to extrahepatic tissues

Oxidative stress also impacts early embryo development and implantation

While more robust human studies are needed, current research suggests it may become an important component of future healthy aging and longevity strategies