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This oxidative burden impairs insulin receptor signaling through serine phosphorylation of IRS, fostering systemic insulin resistance and compensatory hyperinsulinemia (75)

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doi: 10.1002/jcp.26429 144 KanamoriYMurakamiMSugiyamaMHashimotoOMatsuiTFunabaM

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In thalassemia patients, the dysregulation of the glutathione antioxidant system can exacerbate the effects of iron overload

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Notice whats missing from all these studies

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