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Effective management involves optimising nutrition despite reduced appetite, maintaining hydration, addressing gastrointestinal symptoms, and implementing lifestyle modifications to support energy levels

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The SELECT trial demonstrated that semaglutide 2.4 mg reduced major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) by 20% in adults with overweight or obesity and established heart disease (Lincoff et al., SELECT trial, New England Journal of Medicine , 2023)