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Firstly, the permeability of EBA increased after 24-h incubation with 3-PLG-ibu, and secondly, in inflammatory condition besides the 3-PLG-ibu-A-GSH the free ibuprofen treated group also significantly strengthened the integrity of the BBB model for the bigger transcellular marker molecule (Fig

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No se detectaron otros cambios mucocutneos, que los previamente descritos, que se asociaran al uso de erlotinib

2)Targeted therapeutic interventions in vitiligo mainly include therapies targeting IFN--CXCL9/10-CXCR3 axis (IFN- neutralizing antibody, CXCL10 neutralizing antibody, and CXCR3 depleting antibody, as well as JAK inhibitors), anti-CD122 antibody (IL-15 receptor subunit) to decrease IFN- production and deplete autoreactive CD8 + TRM cells, TNF inhibitor to inhibit autoantibody production, and PD-L1 fusion protein to reduce the numbers of melanocyte-reactive T cells