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Edited by: Kleihues P and Cavenee WK

Cold weather slows down cell renewal, reduces sebum production, and constricts blood vessels, limiting oxygen and nutrient flow to the skin

At the beginning of the study, a checklist was utilized to gather demographic and basic clinical data for all patients, including age, gender, body mass index (BMI), alanine aminotransferase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), direct bilirubin, total bilirubin, prothrombin time (PT), and partial thromboplastin time (PTT)

Primary pathological features include hepatic fat accumulation, inflammation, fibrosis, and ballooning degeneration of hepatocytes