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Part of the generated GSH, depending on the needs, can be transported from the cytoplasm to cellular organelles, e.g., the cell nucleus, mitochondrion, endoplasmic reticulum, or GSH may also be effluxed out of the cell into the extracellular medium [34]

Consequently, lower concentrations of Vitamin D3 and zinc may serve as effective treatment options, thereby minimizing the side effect associated with higher doses of Vitamin D3 [327]

Response: We acknowledge commenters' concerns about the staged process for the Overall Hospital Quality Star Ratings reductions, however more than 50 percent of hospitals already receive different ratings year-to-year just as a result of the evolution of the underlying data