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Hossain MA, Kitagaki S, Nakano D, Nishiyama A, Funamoto Y, Matsunaga T, Tsukamoto I, Yamaguchi F, Kamitori K, Dong Y, Hirata Y, Murao K, Toyoda Y, Tokuda M (2011) Rare sugar D-psicose improves insulin sensitivity and glucose tolerance in type 2 diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats

I started a high dose of metformin along with a GLP-1, Mounjaro, which I injected near my belly button once a week

This might also be seen in further prolonged studies (Figure 4, Figure 5 and Figure 6)

For individuals who discontinue treatment and experience significant weight regain, restarting the medication may be considered, though evidence specifically studying this approach is limited