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Interim Results from Week 26 Semaglutide Alone Total Weight Loss: 23 lb Lean Mass Loss: 34.5% (~7.9 lb) Fat Mass Loss: 66.3% Low-Dose Combo (Semaglutide + Low Trevogrumab) Total Weight Loss: 21.6 lb Lean Mass Loss: ~17% (~3.7 lb) Fat Mass Loss: 78.1% Lean Mass Preserved: ~50.8% vs semaglutide alone High-Dose Combo (Semaglutide + High Trevogrumab) Total Weight Loss: 24.8 lb Lean Mass Loss: ~16.8% (~4.2 lb) Fat Mass Loss: 76.3% Lean Mass Preserved: ~51.3% vs semaglutide alone Triplet Combo (Semaglutide + High Trevogrumab + Garetosmab) Total Weight Loss: 30 lb Lean Mass Loss: ~6.6% (~2.0 lb) Fat Mass Loss: 84.4% Lean Mass Preserved: ~80.9% vs semaglutide alone Key insight : All combo treatments preserved significantly more lean mass and enhanced fat loss compared to semaglutide alone

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