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Br J Surg 86: 1296-1301, 1999

Kokkorakis M, Chakhtoura M, Rhayem C, et al

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232 As part of their role in metabolic regulation, Hedgehog proteins promote stem-like features and ensure that CSCs can adapt to environmental pressures, regardless of whether those pressures are energetic (nutrient limitation) or mechanical (tissue barriers)

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