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Abbreviations AIP: Atherogenic-index-of-plasma AC: Atherogenic-coefficient ANCOVA: Analysis of covariance ACO: Acyl-coenzyme-A ACO: Acyl-coenzyme-A oxidase aP2: Adipose-specific fatty acid-binding protein BMI: Body mass index BF%: Body fat-percentage BAI: Body-adiposity-index BIA: Bioelectrical impedance analysis BAT: Brown adipose tissues CVD: Cardiovascular disease CHD: Coronary heart disease CRI-I: Castellis-risk-index-I CRI-II: Castellis-risk-index-II CAD: Coronary artery disease CI: Confidence interval CFU: Colony forming unit CPT-Ia: Carnitine palmitoyl-transferase I-a DBP: Diastolic blood pressure FOS: Fructooligosaccharide FM: Fat-mass FFM: Fat-free mass FFAs: Free fatty acids FIAF: Fasting-induced adipose-factor GPR41: G-protein-coupled receptor 41 GPR43: G-protein-coupled receptor 43 GLP-1: Glucagon-like peptide-1 GDM: Gestational diabetes mellitus HDL-C: High-density lipoprotein cholesterol HC: Hip circumference HSL: Hormone-sensitive-lipase HMG-CoA: Hydroxy-methyl-glutaryl-CoA reductase IPAQ-SF: International physical activity questionnaire-short form ITT: Intention-to-treat LDL-C: Low-density-lipoprotein cholesterol LCI: Lipoprotein-combine-index LBM: Lean body-mass LPL: Lipoprotein-lipase MHO: Metabolically healthy obesity MUO: Metabolically unhealthy obesity MHO: Metabolically healthy obese MET: Metabolic-equivalent-of-tasks MM: Muscle mass NEFAs: Non-esterified fatty acids NSAIDS: Non-steroidal anti-inflammatory drugs NASH: Nonalcoholic steatohepatitis PASS: Power analysis and sample size soft-ware PAL: Physical activity level PDHC: Pyruvate-dehydrogenase-complex PPAR-: Peroxisome-proliferator-activated receptor-gamma PYY: Peptide-YY RCT: Randomized clinical trial (RCT) RAS: Random Allocation Software SD: Standard deviation SCFAs: Short chain fatty acids SBP: Systolic blood pressure TG: Triglyceride TC: Total cholesterol TBW: Total body-water TLR-LPS: Toll-like-receptor-LPS TLR4: Toll-like-receptor 4 VAI: Visceral-adiposity-index VAS: Visual analog scale VLDL: Very-low-density lipoprotein WC: Waist-circumference WHR: Waist-to-hip ratio WHtR: Waist-to-height ratio WAT: White adipose tissue References Blher M (2019) Obesity: global epidemiology and pathogenesis

2024;8:bvae164

Only 1 in 5 people with opioid use disorder and fewer than 8% of those with alcohol use disorder receive treatment