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Contact your GP or prescribing clinician if you experience: Severe or persistent nausea and vomiting that prevents adequate food or fluid intake Signs of dehydration (dark urine, dizziness upon standing, reduced urination) Unexplained, rapid weight loss exceeding 11.5 kg per week consistently Severe abdominal pain, particularly if accompanied by nausea or vomiting (potential pancreatitis) Pain in the right upper abdomen, fever, or yellowing of the skin/eyes (potential gallbladder problems) Recurrent hypoglycaemia, especially if taking other diabetes medications Significant decline in exercise capacity or persistent extreme fatigue Call 999 immediately for: Chest pain or severe breathlessness during exercise Severe hypoglycaemia with altered consciousness Call NHS 111 for urgent but non-emergency concerns when you cannot reach your GP