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On the other hand, the overexpression of G6PD in vascular endothelial cells decreases the accumulation of ROSs in response to exogenous and endogenous stressors, improving bioavailable NO levels [54, 55]

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In heterogeneous tumor environments, achieving selective targeting of mutant p53 cells without damaging wild-type p53-dependent normal cells is a major challenge, mainly for the following reasons: some drugs targeting mutant p53 may also be toxic to wild-type p53 cells, and the complex tumor microenvironment may affect the efficacy of drugs

DMF upregulates DNA hydroxymethylation We first determined whether DMF treatment mediates global or CBS locus-specific DNA methylation/hydroxymethylation (5mC/5hmC) modifications