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Research Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers Gobburu JV, Agers H, Jusko WJ, Ynddal L (2004, October) This study highlights advances in understanding how ipamorelin behaves and acts within the human body

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During the initial stage, there is an immediate increase of catecholamines via activation of the sympathetic preganglionic neurons in the spinal cord, which in turn stimulates adrenal medulla production of catecholamines via splanchnic nerve innervation

Clinicians should screen each patient for metabolic, endocrine, and cardiovascular factors to ensure safe use