Experimental receptor assays demonstrate that GLP-RT functions as an agonist at all three receptors, although the peptide exhibits differing potency levels across the receptor set
Patients with a history of nausea, diarrhea, constipation, diabetes, hypoglycemia (low blood sugar), pancreatitis, gallbladder disease, or gastric surgery should talk to their healthcare provider before starting these medications
Off-label use in longevity discussions is based largely on animal research showing lifespan extension, but controlled human longevity data remains limited
Blood 90 : 935943 Villunger A, Egle A, Kos M, Hartmann BL, Geley S, Kofler R and Greil R (1997) Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells