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The slow, sustained absorption profile is one reason semaglutide requires once-weekly dosing rather than daily administration

We estimated insulin resistance by HOMA-IR equation instead of performing an oral glucose tolerance test

That being said, an alternative measure was used by the research team that assessed motor function by grading the toe and heel foot print characteristic on a scale from 0-4, with 0 defined as no print, non functional, and 4 defined as complete print, near normal functioning [2]

Severe hypoglycaemia indicates clearly that the insulin dose is too high requiring a more substantial correction