These drugs mimic the effects of the naturally occurring GLP-1 hormone, which is produced in the small intestine and plays a crucial role in regulating insulin secretion, glucose homeostasis, and appetite
Molecular Endocrinology, 27 , 12341244
Even in diabetic animal models, RYGB and/or VSG reduced -cell dedifferentiation (RYGB, diabetic GotoKakizaki rats) 59 , improved -cell identity markers (VSG, young db/db mice 60,61 ) and increased islet insulin content (RYGB, Zucker diabetic fatty rats 62 )
Those with a history of pancreatitis or thyroid cancer Individuals using the drug solely for vanity weight loss without medical need Pregnant or breastfeeding women Ultimately, consultation with a licensed medical provider is essential