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Description

Frataxin-knockout mouse myoblasts, heart, and skin fibroblasts all showed characteristics of ferroptosis, and Nrf2 was downregulated in Friedreichs Ataxia patients and frataxin-knockout mice, while Nrf2 activators EPI-743 or sulforaphane regulated redox imbalances and rescued ferroptosis in frataxin knockout cells

BMC Genomics 26:218

Enhances neuroplasticity potentially improving visual processing

The nonclassical pyroptosis pathway Unlike the classical pathway, the nonclassical pathway is triggered by cytosolic lipopolysaccharide (LPS) stimulation

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