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FIGURE 3 3.1 The effect of uremic toxins The progression of CKD is accompanied by the accumulation of diverse uremic toxins, which significantly accelerates the process of eryptosis

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Although LDHA has been extensively characterized as a tumor survival factor through its role in mitigating ROS, targeted depletion via small interfering RNA or pharmacological inhibition (GSK2837808A or R-GNE-140) fails to sensitize A549 cells to ferroptosis inducers, including RSL3 or erastin (49)

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