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Encourages lipolysis (fat-to-fuel conversion) while preserving lean tissue

As an active metabolite synthesized by intestinal microbiota, the increased level of TMAO is associated with increased risks of CAD and all-cause mortality (130, 131)

In many real-world cases, paresthesia is more plausibly linked to what changes around GLP-1 therapy, shifts in blood sugar, reduced intake, dehydration and electrolytes, nutrient deficiencies, or compression neuropathies after weight loss

Through mechanisms that lower LDL and triglycerides, raise HDL cholesterol, and address insulin resistance, semaglutide can support a more balanced lipid profile and healthier heart