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The infiltration of immune cells such as macrophages, neutrophils, mast cells, B cells, T cells, NKT cells within the adipose tissue, coupled with the overproduction of inflammatory mediators and adipokines (e.g., leptin and lipocalin), adipocyte-derived MCP-1 and hypertrophy of visceral adipocytes, leads to hypoxia, autophagy, and apoptosis (130)

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811 In addition, other antioxidant, or herbal active substances, including resveratrol, gossypol acetic acid, galangin, kinsenoside, hydroxysafflor yellow A, baicalein, and luteolin, also improve myocardial I/ R injury by inhibiting ferroptosis

Impaired autophagy triggered by HDAC9 in mesenchymal stem cells accelerates bone mass loss