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The FDA has approved Zepbound for use with diet and exercise in adults with a body mass index (BMI) of: 30 or higher (obesity), or 27 or higher with a weight-related health condition, such as high blood pressure, high cholesterol, type 2 diabetes, sleep apnea, or heart disease

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However, these analyses often included smaller trials with shorter follow-up, which may increase heterogeneity and reduce reliability regarding long-term cardiovascular and safety outcomes

For brain and nervous system health and prevention of disease in older adults, serum B12 levels should be maintained near or above 1000 pg/ml