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Additionally, iron overload in ferroptosis is further modulated by key metal ion transporters, including solute carrier family 39 member 14 (Slc39a14) and solute carrier family 39 member 8 (Slc39a8) ( Together, the processes of ferritinophagy, mediated by NCOA4, and enhanced iron import via Slc39a14 and Slc39a8 synergistically increase intracellular iron levels, solidifying their roles as critical factors in regulating ferroptosis

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