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doi: 10.1002/oby.24302

Cardiovascular data on endpoints like MACE-3 or MACE-4 are presently not available yet, but an early meta-analysis demonstrated at least cardiovascular safety in patients with T2D treated with tirzepatide (78, 79)

The body has already adapted to substantial receptor activation

Lifestyle is still required for long-term success: Whether youre on GLP-1s alone, HRT alone, both, or neither, the fundamentals still determine your results: Resistance training 2-4x weekly High protein intake daily Adequate sleep (7-9 hours) Stress management Sustainable calorie deficit Medications can make these things easier to achieve, but they dont replace them