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No significant drug interactions between spirulina and standard alcohol detox medications (such as benzodiazepines, naltrexone, or acamprosate) have been documented in the clinical literature

Patients with higher plasma TMAO levels achieved better responses to immunotherapy due to TMAO-induced pyroptosis in tumor cells and enhanced CD8 + T cell-mediated antitumor immunity (237)

Oral NMN at maintenance doses has an excellent safety profile at doses up to 1,000 mg/day in clinical studies

Interestingly, these effects were more pronounced in the high-dose APLA group compared to PLA, suggesting dose- and type-dependent neurotoxicity (Qian et al., 2025)