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It stimulates ACTH and cortisol release (likely through hypothalamic CRH activation), increases prolactin secretion, and potently stimulates appetite through ghrelin-mimetic activity at the GHS-R1a receptor in the arcuate nucleus

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Key takeaways Berberine and Zepbound affect similar metabolic pathways Combining them may increase side-effect risk Blood sugar effects can stack unexpectedly Supplements still require medical review Provider guidance helps avoid complications Can You Take Berberine And Zepbound Together