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The synergistic activation of these receptors through triple therapy leads to amplified effects on weight reduction, enhanced glycemic control, and improved lipid profiles across multiple tissues, including the pancreas, brain, liver, and adipose tissue

Response: While we note that APC geometric mean cost changes are expected under the current structure of the C-APCs and the complexity adjustments, we agree that a Level 3 Nerve Procedures APC is appropriate, in particular to resolve what would otherwise be a significant two times rule violation in the Level 2 APC

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