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Regarding ERT, efficacy is greatly conditioned by the initiation age, approved enzymes have low tissue penetration and none of them crosses the bloodbrain barrier (BBB), administration causes infusion associated reactions and may induce the production of anti-drug antibodies with neutralizing effect, requires lifetime i.v

Detailed menstrual history-taking requires specific training and time allocation that many current clinical encounters lack

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5 Gruppen wurden als Kontrollen verwendet: 2 Gruppen waren ovariektomisiert, mit Salzlsung behandelt und wurden am 15