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In contrast, obesity may be associated with increased circulating prolactin levels, which are potentially mediated by adipose tissue expansion, enhanced aromatase-dependent estrogen production, and chronic low-grade systemic inflammation

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Its enzymatic function is based on two aspects: its catalytic activity and the auto- S -glutathionylation of GST by itself on Cys47 and Cys10, both of which disturb the subsequent interaction with c-Jun NH 2 -terminal kinase (JNK), resulting in the formation of a GST multimer 30 (Figure 3)

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