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Nationwide retrospective studies utilizing register data from Sweden and Denmark (20132021) and the UK CPRD (20072020) have revealed consistent findings, indicating that GLP-1 RAs are not associated with an elevated risk of suicidality relative to DPP-4 or SGLT-2 inhibitors [77,78]

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The STEP-9 trial showed patients with knee osteoarthritis taking semaglutide experienced marked improvements in pain scores along with significant weight reduction 39